What work by Harriet Beecher Stowe addresses the issue of slavery?

The correct choice is "Uncle Tom's Cabin," which is a seminal work that played a pivotal role in shaping public opinion about slavery in the United States. Published in 1852, the novel tells the story of enslaved African Americans and highlights the brutal realities of slavery through its characters, particularly Uncle Tom, a kind and dignified slave. Stowe's portrayal of the inhumanity and moral dilemmas faced by both enslaved individuals and slave owners was influential in galvanizing the abolitionist movement. The novel is often credited with laying the groundwork for the Civil War by stirring empathy and anger among Northern readers who were previously indifferent to the plight of enslaved people.

The other options, while notable works by Stowe, do not primarily address slavery. "The Minister's Wooing" explores religious themes and the role of women in society, "Palmetto-Leaves" is a travelogue that reflects on Southern life, and "The Pearl of Orr's Island" focuses on life in a small Maine community, dealing more with the themes of love and community than with the issue of slavery. Thus, "Uncle Tom's Cabin" stands out as the specific work that directly tackles the subject of slavery.